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Side Effect Comparison All three compounds produce the same underlying GI side-effect pattern nausea, diarrhea, vomiting, constipation because they all slow gastric emptying and activate brainstem pathways that regulate nausea

So from a primary care frontline clinicians perspective, what do you wish more primary care doctors knew about GLP-1 medications

In addition to the regulation of appetite and satiety that recently has attracted much attentions, insight has also been gained into the critical role of leptin in the control of the insulin-glucose axis, peripheral glucose and insulin responsiveness

From receptor pharmacology and weight loss percentages to gastrointestinal side effects and body composition changes, every comparison here draws from published clinical trial data

If you experience suspected side effects from any medicine, you can report them to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk

Glutamatergic medications can act as receptor antagonists, reuptake inhibitors, co-agonists, and ion channel modulators